Therapeutic and Human Heritable Genome Editing
1. Overview of Therapeutic Genome Editing
Greg Davis (Sangamo) Christine Moburg (Sangamo) Nicola Worsfold (Jessie’s Journey)
. What is genome editing and how
. does it differ from gene replacement?
. What are tools/techniques of genome editing?
. What are applications for genome editing in treating
. What therapies are available?
2. Human Heritable (Germline) Genome Editing: Social, ethical, and policy implications
Ron Pearlman (York University) Nick Meade (Genetic Alliance UK) Ian Stedman (York University)
. What is germline genome editing?
. How is it similar to and differ from therapeutic?
. genome editing?
. What are potential applications?
. What are social, ethical, and policy issues? What is current status?
3. In-class skills development exercise: Scenarios on genome editing
Format: breakout session
. What is germline gene editing?
. What are the controversies?
. Are there circumstances where it could be acceptable?
. Should WHO develop global policies and how could these be enforced?