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ICMRS Scientific Frontier Webinar Series - Shared screen with speaker view
Xu Cao
If you have questions, please write here. We will Prof. Zou answer your question at the end of his lecture
Y Qin
Wonderful and beautiful works. You talked about OB and OC with piezo1. Do you think about osteocytes in piezo1?
Chike Cao
Great talk. What about knockout Piezo1 in adult stage in bone cells? Any phenotypes?
Weizou, great talk. If I understand you correctly, Piezo regulates Col1 production which would predict bone formation defect in the knockout, but that’s not what you saw. Can you please clarify?
Matt Greenblatt
Fantastic talk Weiguo and an impressive body of work. Can you say a little more about the characteristics of the population that is differentially represented in LSD1 prx1-cre vs control single sell seq studies? Do these cells express detectable PRX1?
Cartilage formation help but is not required for fracture healing. For example, rigid compressed fixation of fracture results in fracture healing without cartilage formation. The function of cartilage formation is to stabilize fracture to help fracture healing. LSD1-/- mice do not have cartilage formation, which can result in the instability of the fracture to lead non-healing. Can you use the rigid compressed fixation, similar to clinic, to improve the fracture healing in LSD-/- mice?
Chao WAN
Thanks Weiguo for the wonderful lecture. Is there any difference in LSD1 regulation on chondrocyte differentiation during growth development and impaired fracture repair in the LSD1 mutant mouse?
David Ke
very nice presentation. Can you discuss the effect of LSD1 on intramembranous ossification during fracture healing?
Y Qin
Further question: the mechanical influence was mainly discussed on disuse, like suspension. It is obvious for OC activity. How about positive loading, which OB would play more important role. Thus, cellular responses may be different, so as the osteocytes, which is considered mechanosensing cells.