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How does Shp2 regulate PKA?
Wentian, thanks for the great talk. The hairy phenotype is very interesting. Are the hair follicle of the prx1cre shp2 cko mice have gene deletion? You show that the chondrocyte has elevated wnt signaling, which is a key regulator of hair follicle dev and function.
Wentian: excellent work! Your prx1-Cre CKO have expanded cartilage area. Is it possible that cartilage degradation by MMPs or RANKL-stimulated OCs are blocked?
Great talk. SH2 belongs to src kinase family, It is well known that src is required for ruffled border formation but not osteoclast formation. TRAP+ osteoclasts are increased in src-/- mice while there is no osteoclasts in SH-/- mice. What is the difference of SH2’s function com[pared to src?
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Since Ctsk Cre targets periosteal stem cells, in your SHP2 knockout mice, what is the phenotype of these stem cells?
Do you find any phenotype in the tendon?
X. Edward Guo
Wentian, great talk and great work! Good night everyone!
Thank you, Wentian. You did a great detective work!