People of all ages develop sepsis, but older adults are disproportionally affected. Individuals over 65 years old, particularly those who have health issues, are more susceptible to sepsis than any other group. This webinar will discuss the incidence of sepsis in older adults and the physiologic aging process making seniors at higher risk to develop sepsis. Basic sepsis pathophysiology will be reviewed along with differentiation of sepsis and SIRS. Challenges of sepsis recognition and treatment considerations will be presented.