THE DIFFERENCE BETWEEN LEFT AND RIGHT:
VIBRATIONAL CIRCULAR DICHROISM AT WORK FOR ANALYTICAL CHEMISTRY
Very often, the absolute configuration of chiral centers of complex APIs, proteins or natural products is initially unknown and tricky to determine. Singly crystal X-ray crystallography is the method of choice, if single crystals are available and representative – but what, if not?
Vibrational Circular Dichroism (VCD) is based on IR spectra of left and right circularly light. Measurements can be performed in liquid, dissolved, gaseous or any solid form. Key is not only the measurement, but also the computed spectra of specific Absolute Configurations and the data comparisons.
For molecules with multiple chiral centers, VCD is an absolute and independent technique that directly probes the chirality at multiple chiral centers in a single measurement. There are various stages at which VCD is best performed. One is for example in the beginning of a study of complex enantiomers to establish the right configurations and the respective references for chiral HPLC.
THE PRESENTATION WILL COVER:
- Practical applications for chiral molecules characterisation by VCD
- Some theoretical aspects of VCD
- New uses and experiences of VCD
- Q&A sessions
WHO SHOULD ATTEND
The webinar is compact and ideally suited for industry representatives from R&D, product development and analytical departments as well as researchers from academia interested in real use of VCD.
The presentation will be recorded. If you register and cannot attend you will receive the link to the recording afterwards.