Signaling pathway crosstalk, dynamic multicellular interactions, bidirectional cell-matrix feedback loops, oh my! It is becoming more apparent that understanding matrix biology relies on our ability to integrate multifaceted processes that operate across complex, interconnected systems. To that end, many research groups are developing computational modeling approaches to help grapple with these system-level complexities in order to elucidate biological regulation and identify novel therapeutic interventions. Such groups have made exciting advances across spatial scales (from molecular-level matrix binding events to organ-level matrix performance), across temporal scales (from millisecond-long biochemical reactions to years-long chronic in vivo remodeling), and across the gamut of ECM processes (signaling, expression, assembly, maturation, degradation, etc.). In this "Matrix Math" e-Symposium, we will host cutting-edge talks that utilize computational tools for understanding extracellular matrix regulation.
Chaired by: William Richardson, Clemson University