Singapore has topped the world in life expectancy, but this achievement is of little value if old age is riddled with dementia and age-related illnesses. Eternal youth may be a distant dream but aging healthily can be achieved by understanding the precise molecular mechanisms that regulate aging.
Gastrointestinal aging and the associated loss in gut microbiome diversity seems to play a key role in age-related functional decline. Our gut-brain axis can also be affected by an unhealthy gut barrier. A leaky gut leads to increased levels of pro-inflammatory mediators in the bloodstream, causing neuroinflammation in the brain that results in cognitive decline.
An aging gut faces a widening Nutrient Gap. As we grow older our bodies require fewer calories and we should eat less. Our aging brain, however, requires more micronutrients which our aging gut is unable to supply due to loss of function. Intake of super-nutrient supplements to enhance immunity and reduce oxidative damage may help to prevent age-related disease and disability.