Behavioral and Psychological Symptoms of Dementia (BPSD) are common and challenging, with no consistently safe or effective pharmacological or non-pharmacological treatments available. In this symposium, current evidence will be reviewed for the use of antipsychotics, serotonin specific reuptake inhibitors and mood stabilizers, in addition to dronabinol, prazosin, dextromethorphan/quinidine, pimvanserin and ECT. This will be followed by a discussion of possible biological mechanisms of BPSD throughout the spectrum of Alzheimer’s disease severity, which may be useful for treatment development. Focus will be on areas with the best evidence, which includes agitation and apathy in established AD, and depression, anxiety and apathy in preclinical and prodromal AD. Other important contributing factors to BPSD include physical and social conditions, as well as the dynamic between caregivers and persons with dementia. Findings will be discussed from the MIND at Home multidisciplinary intervention, which is designed to support persons with dementia and their caregivers at home in the community. This symposium will end with a review of evidence-based models of integrated dementia care and discussion of the experiences of developing and launching an integrated dementia care team using a collaborative care approach across Mass General Brigham, a large and diverse health care system.