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Bioactive Marine Natural Products: Drug Leads and Cell Biology Tools
Cystic fibrosis (CF) is a lethal genetic disease most frequently caused by a F508del mutation in the cystic fibrosis transmembrane regulator (CFTR), a chloride ion transport channel. Mutant F508del-CFTR is flagged for proteolytic degradation by the protein quality control machinery in the endoplasmic reticulum (ER), preventing its trafficking to the plasma membrane and leading to the CF disease state. If the mutant F508del-CFTR protein reaches the plasma membrane it is still functional as a chloride channel and, therefore, an attractive approach to treating CF would be the use of small molecule ‘correctors’ that rescue the trafficking of F508del CFTR protein to the plasma membrane. This WEBinar will describe our use of a Chemical Genetics approach to discover the sponge natural product latonduine A, a potent F508del-CFTR trafficking corrector. It will also describe in detail how we have identified its novel dual protein target mechanism of action. Latonduine A is a promising lead compound for developing a new class of F508del-CFTR trafficking corrector drugs.

Dec 2, 2020 02:00 PM in Sao Paulo

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Speakers

Prof. Raymond J. Andersen
Bioactive Marine Natural Products: Drug Leads and Cell Biology Tools @University of British Columbia
Professor Raymond J. Andersen is a Professor of Chemistry at UBC and is internationally known for his research on marine natural products and their potential as drug leads. His discoveries have represented core technologies of Aquinox Pharmaceuticals and Inflazyme Pharmaceuticals and his industrial programs have led to deals with Aventis and Wyeth and the venture capital arms of Johnson & Johnson and Pfizer. Dr. Andersen received his B.Sc. from the University of Alberta, an M.Sc. from UC Berkeley, a Ph.D. from UC San Diego, and he was a post-doctoral Fellow at MIT. Dr. Andersen is a Fellow of the Royal Society of Canada and he has received the Chemical Institute of Canada Medal, the UBC Jacob Biely Research Prize, and the American Society of Pharmacognosy Farnsworth Award.