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The timeous and economic deployment of new generation reactors has several barriers to overcome with some examples being (1) qualified high temperature material (2) large scale fabrication and integration of components through welding processes (3) suppliers with NQA-1 qualification and (4) environmental testing facilities. Additionally, barriers for first entrée to market are the perception that new materials and the associated manufacturing techniques are too arduous and therefore not a thought within the design decision framework. Various organizations and working groups, both national and international, are working together to debunk the perceptions, with strong and focused industry focused research to systematically address the technical barriers. Additionally, the paradigm for material research has changed significantly over the past decade, to ensure fully integrated material and manufacturing development, therefore not only accelerating the development processes, but also to ensure that it is manufacturable and that unique or enhanced properties are being generated. Although additive manufacturing processes are known to have beneficial opportunities to leverage for new reactor designs, various other advanced manufacturing processes are available to be explored. This presentation will provide an overview of the GIF Advanced Manufacturing and Materials Engineering working group (AMME WG) and the collaborative research in process to highlight the role that advanced manufacturing can have on the deployment of Gen IV systems. Additionally, opportunities of various other manufacturing processes are discussed with potential key applications. As there is no “one recipe fits all”, it is important that a designer and developer should explore the behavior of the component material-manufacturing process combo over the full lifecycle. The presentation will close by providing an brief overview of the US Advanced Materials and Manufacturing Technologies program.