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SONA Webinar: Roles of microglia in the pathogenesis of neurodegeneration
Abstract

Microglia are implicated in a variety of functions in the central nervous system, ranging from shaping neural circuits during early brain development, to surveying the brain parenchyma, and providing trophic support to neurons across the entire lifespan. In neurodegeneration, microglia have been considered for long time mere bystanders, accompanying and worsening neuronal damage. However, recent evidence indicates that microglia can causally contribute to neurodegenerative diseases, and that their dysfunction can even be at the origin of the pathology. In fact, the broad range of physiological roles microglia play in the healthy brain suggest that faulty microglia can initiate neurodegeneration through several possible mechanisms. In particular, in this seminar, we will discuss how dysfunctional microglia can affect synaptic function leading to pathological synapse loss, thus putting microglia center stage in the pathogenesis of brain disorders.

Jun 17, 2021 05:00 PM in Johannesburg

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Speakers

Rosa Paolicelli
Dr @University of Lausanne, Switzerland
Short Bio: Dr Rosa C. Paolicelli is an Assistant Professor at the Department of Biomedical Sciences, Faculty of Biology and Medicine at the University of Lausanne in Switzerland. She leads research on the role of microglial cells in the healthy and diseased brain. Rosa’s lab studies the roles of microglia in network refinement during development and in neurodegenerative diseases.