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How kinase ubiquitination regulates mitosis in cancer
Cell cycle dysregulation is a common driver of tumorigenesis. In clear cell renal cell carcinoma (ccRCC), the mitotic checkpoint is disrupted via the loss of the E3 ubiquitin ligase complex subunit VHL which contributes to over expression of Mps1 and disrupted cell cycle exit from the mitotic checkpoint. Therefore, VHL-mediated ubiquitination of Mps1 regulates mitotic checkpoint progression. Further, Mps1 stability additionally mediates Hsp90 post-translational modification and effectiveness of Hsp90 inhibitors in treating cancer, providing insight for future treatment options for ccRCC.


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