Cigarette smoking is the leading preventable cause of death. Tobacco use is established primarily during adolescence and young adulthood, with 99% first trying by age 26 (USDHHS, 2012). Despite declines in adolescent cigarette smoking, overall tobacco product use by high school students actually increased in recent years (Gentzke et al., 2019). This is largely due to dramatic increases in electronic nicotine delivery system (ENDS) use (“vaping”), the most common nicotine/tobacco product used among adolescents. Indeed, the increase in past-month nicotine vaping by 12th graders from 2017 (11.0%) to 2018 (20.9%) was the largest for any substance tracked by the national Monitoring the Future (MTF) study in over 40 years (Miech et al., 2019a) and continued to grow in 2019 to a record 1 in 4 (25.4%) 12th graders (Miech et al., 2019b). Vaping can take numerous forms, including dripping, a practice linked to higher levels of carcinogen exposure. In addition, nicotine salt products, such as Juul and Puff Bars, were large drivers of the dramatic increases in youth uptake of e-cigarettes. This is likely due to their ability to allow the inhalation of large levels of nicotine without the aversiveness associated with standard nicotine products. This presentation will review both dripping and nicotine salts.