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A multi-organ-on-chip MIVO®-based platform to recapitulate the immune cells' circulation, infiltration and cytotoxic activity against cancer cells.
The success of immunotherapeutic approaches strictly depends on the interaction of the immune cells with cancer cells. While conventional in-vitro cell cultures under-represent the complexity and dynamic crosstalk of the tumour microenvironment, animal models do not allow deciphering the anti-tumour activity of the human immune system.
Therefore, it becomes mandatory the adoption of organ-on-chips (OOC)- as predictive preclinical models for the screening of immune-therapeutic approaches.

In this webinar, we will present our recent data on the immune cell Natural Killer (NK) migration under physiological fluid flow, recapitulated within the MIVO device, infiltration within a 3D tumour matrix, and activation against neuroblastoma cancer cells in a humanized, fluid-dynamic environment.

The proposed immune-tumour MIVO-based model represents a promising approach for faithfully recapitulating the human pathology and efficiently employing the immunotherapies testing, eventually in a
personalized perspective.

Sep 21, 2022 03:00 PM in Rome

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