Deciphering the effect of bacteria on protein conformational diseases

Gut dysbiosis is increasingly associated with the pathogenesis of protein conformational diseases such as Parkinson’s and ALS. Therefore, understanding the microbial contribution to protein stability and disease is critical for developing more effective interventions. The Czyz lab employs C. elegans with Enzo’s PROTEOSTAT® AGGREGATION ASSAY kit to detect bacteria-induced changes in the protein folding environment resulting in aggregation and pathogenicity. Overall, the Czyz lab reveals that detrimental bacteria disrupt host proteostasis and contribute to disease pathogenesis in the C. elegans model.

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