One year into the pandemic, we know more about the virus, the vaccination, risk, and the immune system response. With the COVID-19 pandemic still affecting communities all over the world and “Long Haul” chronic health issues emerging, it is time for us to look back at past multi-symptom health conditions that required a different approach to their treatment, beyond just managing symptoms. It is important for us to consider how to apply what we have learned about immune rejuvenation and its impact on conditions associated with chronic immune dysfunction. The pandemic has challenged and reshaped medicine like never before. We are witnessing a rapid reinvention of medicine presenting unique opportunities for the Functional Medicine Community to lead the field with new clinical models and cutting-edge, personalized, lifestyle-based strategies to prevent and reverse chronic disease.