Due to the poor predictability of preclinical assays, oncology clinical trials have a low success rate. Therefore, the validation of novel experimental assays is essential for a more accurate assessment of novel cancer treatments. We will show an innovative multi-compartmental configuration of the MIVO platform to fluidically connect 3D ovarian cancer tissues to hepatic cellular models and simulate the systemic administration of cisplatin.
This approach enables a simultaneous investigation of drug efficacy and hepatotoxic effects in a physiological context. Most notably, toxicity and efficacy results from an experimental strategy integrating 3D culture, fluid-dynamic conditions, and multi-organ connectivity are the most accurate if compared to clinical data, proving that OOC-based strategies are trustworthy 3Rs alternatives in preclinical settings.