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A Tumor-Liver Multi-Organ-on-chip for assessing simultaneously anticancer drug efficacy and hepato-toxicity.
Due to the poor predictability of preclinical assays, oncology clinical trials have a low success rate. Therefore, the validation of novel experimental assays is essential for a more accurate assessment of novel cancer treatments. We will show an innovative multi-compartmental configuration of the MIVO platform to fluidically connect 3D ovarian cancer tissues to hepatic cellular models and simulate the systemic administration of cisplatin.
This approach enables a simultaneous investigation of drug efficacy and hepatotoxic effects in a physiological context. Most notably, toxicity and efficacy results from an experimental strategy integrating 3D culture, fluid-dynamic conditions, and multi-organ connectivity are the most accurate if compared to clinical data, proving that OOC-based strategies are trustworthy 3Rs alternatives in preclinical settings.

Jan 27, 2023 04:00 PM in Rome

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Dr Chiara Vitale
PhD student in Clinical & Experimental Immunology @University of Genoa
Dr Silvia Scaglione
Chief Scientist @React4life