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Sleep disturbances in persons with Down syndrome: importance of detection and early intervention
Webinar is on 21th April 2021, at 17.00h till 18.00h CET. (Please change your time zone while filling registration form)

Webinar language is English*.
*Es gibt eine Übersetzung vom Englischen ins Deutsche.
* İngilizce'den Türkçe'ye çeviri yapılacaktır.

Jacqueline London - Emeritus Professor at University Paris-Diderot

Sleep disturbances both in early childhood of persons with DS have been mostly under estimated especially on their consequences on physical and neural development and functionning. Many international recent reports have shown that 60% of the children with DS syndrome aged even 4 months have OSA (Obstructive Sleep Apnea) even if they do not snore and if their parents report not to have any sleep problem.
These patients have not only sleep apneas but also sleep fragmentation (frequent sleep arousals without apnea) and also sleep disorders breathing (SDB) which are important for normal development. We will give some new practical information to better handle with these problems in the population with DS according to ages. A specific mention will be given also to the relation between apnea and COVID-19 in these days of pandemia.

Apr 21, 2021 07:00 PM in Istanbul

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Jacqueline London
Emeritus Professor @University Paris-Diderot
She has completed her PhD in the Pasteur Institute under the direction of Pr. Jacques Monod and Professor M. Goldberg in the field of protein folding and bacteriology. She moved to immunology in Necker’s hospital under the direction of Pr. JF Bach and then was a visiting scientist at NIH. She settled a laboratory in molecular biology at the Blood Center and cloned glycophorins A and B. She worked on Down syndrome (Trisomy 21) and published some 35 papers on different aspects of trisomy 21 using transgenic mice for some chromosome 21 genes: APP, CBS, DYRK1A and SOD1 in Necker’s Hospital. She published the first research papers on sleep in animal models for DS and give several talks on sleep problems in DS which were not recognized as a real phenotype in the early 2000. Since many years she tried to push the correlation between Alzheimer disease (AD) and Down syndrome (DS) and recently worked on neurotransmitters in some transgenic mice APP, and DYRK1A.