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Do More Single Cell with Less: Tapestri Platform Expansion for Hematologic Malignancy Research
Join Mission Bio on Tuesday, September 21st at 8:00 AM PST | 11:00 AM ET | 5:00 PM CET to hear the highlights of the Tapestri Platform expansion and learn how you can do more single cell in less time with lower sample input to enable new avenues for your research that were previously impossible.

We'll be joined by Dr. Koichi Takahashi of MD Anderson Cancer Center who shares his work in AML research using novel multi-omics applications.

Speaker Abstract:
Clonal diversity is a consequence of cancer cell evolution driven by Darwinian selection. Precise characterization of clonal architecture is essential to understand the evolutionary history of tumor development and its association with treatment resistance. Here, using single-cell DNA sequencing, we report the clonal architecture and mutational histories of 123 acute myeloid leukemia (AML) patients. The single-cell data reveals cell-level mutation co-occurrence and enables reconstruction of mutational histories characterized by linear and branching patterns of clonal evolution, with the latter including convergent evolution. Through xenotransplantation, we show leukemia-initiating capabilities of individual subclones evolving in parallel. Also, by simultaneous single-cell DNA and cell surface protein analysis, we illustrate both genetic and phenotypic evolution in AML. Lastly, single-cell analysis of longitudinal samples reveals the underlying evolutionary process of therapeutic resistance. Together, these data unravel clonal diversity and evolution patterns of AML and highlight their clinical relevance in the era of precision medicine.

Stay for the whole event and receive a $50 UberEats voucher on us.

*Participants must stay until the end of the event in order to receive the UberEats voucher. Employees of Mission Bio and its competitors are ineligible.

Sep 21, 2021 11:00 AM in Eastern Time (US and Canada)

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Koichi Takahashi , MD, PhD
Assistant Professor @MD Anderson Cancer Center
Dr. Takahashi earned MD degree from Niigata University School of Medicine, Japan in 2006. He then completed two internal medicine residency, the first one in Toranomon Hospital, Tokyo, and the second in Beth Israel Medical Center, New York. He came to MD Anderson Cancer Center in 2011 as an Hematology/Oncology fellow and completed fellowship in 2014. During this time, Dr. Takahashi did postdoctoral fellowship under the mentorship of Dr. Andrew Futreal. He is board certified in Internal Medicine, Hematology and Medical Oncology. Currently, Dr. Takahashi is an Assistant Professor in the Department of Leukemia with a joint appointment at the Department of Genomic Medicine. He is a physician-scientist focusing on genomic characterization of leukemia. Dr. Takahashi is an awardee of Celgene Future Leaders in Hematology (2012), Achievement in Basic Research at UT MD Anderson Cancer Center, and Khalifa Scholar Physician Scientist Award (2016).
James Flynn
Senior Product Manager @Mission Bio