Regardless of whether you experienced an infectious disease, your immune system has suffered in the past couple of years. As we work to restore immunity in our post pandemic world, we must be aware of how our immune systems have been affected by SARS-CoV2 infection, social isolation, insomnia, and anxiety. We know diets and nutritional habits changed; work/life balance changed; and stress increased beyond our wildest projections. This seminar will discuss immune health in the context of our individualized microbial ecosystems, our hormones, and environmental exposures. We will highlight our current understanding of how the gut microbiome and immune system interact to achieve health, as well as how the microbiome is affected when we reconnect with each other. Finally, we will discuss a strategy to support immune rejuvenation in yourself and your patients.