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ISIMM - State of the Art and Science of Immunocytochemistry
Immunocytochemistry (ICC) has become an indispensable ancillary method in a modern cytopathology for fine-tuning a diagnosis as well as for assessing prognostic and predictive markers. As shown by recent survey performed by European Federation of Cytology Societies (EFCS), ICC is extensively used in European cytology laboratories on a differently prepared and fixed cytology slides. Formalin-fixed paraffin-embedded (FFPE) cell blocks are regarded the optimal choice for ICC from QA/QC perspective, however low cellular cell blocks with insufficient cells are the main issue in a daily cytology practice as shown by the survey performed among European and USA laboratories. Other cytology slides are therefore vital to perform ICC on a limited and low cellular cytology samples. The basic requirements to assure reliable ICC results on non-FFPE cytology preparations are control slides prepared as the patient sample as well as optimization and validation of ICC protocols.

At the end of the session, participants will be able to:

• Demonstrate the role of immunocytochemistry (ICC) in a modern cytopathology
• Present the current landscape of immunocytochemistry in Europe
• Discuss application of QA/QC measures for reliable ICC
• Describe parameters to assess quality of ICC on cytology slides

Speaker: Irena Srebotnik Kirbiš, Faculty of Medicine, Institute of Pathology, University of Ljubljana, Ljubljana, Slovenia

Host: Heather Dow, CAP-ACP Executive Director

Target audience: Pathologists

CanMEDS Roles: Medical Expert

This event is an Accredited Group Learning Activity (Section 1) as defined by the Maintenance of Certification Program of the Royal College of Physicians and Surgeons of Canada and approved by the CAP-ACP. You may claim a maximum of 1.5 hours per event attended. (credits are automatically calculated).

Declaration of Conflict of Interest:
UK NEQAS ICC : assessor


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Irena Srebotnik Kirbiš
Faculty of Medicine @University of Ljubljana
Srebotnik Kirbiš Irena graduated in 1988 on Biotechnical Faculty, University of Ljubljana and finished her PhD at Faculty of Medicine, University of Ljubljana in 2018. She started her career in cytopathology as a cytotechnologist in 1989 at the Department of Cytopathology, Institute of Oncology, Ljubljana, Slovenia working in the field of immunocytochemistry and quality improvement. In 2007 she accepted a new post as a Biomedical Scientist at the Institute of Pathology, Faculty of Medicine, University of Ljubljana. She is a representative of Slovenia in EACC since 1997 and assessor in two external quality programmes for cytology - UK NEQAS for immunocytochemistry since 2004 and in UK NEQAS CPT since 2014. She is author and co-author of several original papers on immunocytochemistry and cytopathology.