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Annual INS Presidential Invitational Webinar
Title: Cognitive Neuroscience comes of Age: Using Closed-loop Neuromodulation to induce clinical change

with Alex Martin, PhD - Acting Chief, Laboratory of Brain & Cognition, National Institute of Mental Health, Bethesda, MD

Level of Instruction: Intermediate

CE optional 1.0 Credit Hours at an additional cost
$20 Members
$30 Non-Members

Abstract & Learning Objectives:
During the past several decades we’ve witness tremendous advances in our ability to study human brain function. Now, for example, we can probe processing differences at the level of the cortical laminar, and identify the brain’s intrinsic network architecture via recording slowly fluctuating, spontaneous neural activity at rest. Yet, despite these and other advances, we have little to show for it on the treatment front. In this webinar, I will highlight recent advances in functional neuroimaging that may potentially offer a means for modifying aberrant neurocircuitry in neuropsychiatric patients. This method, closed-loop neuromodulation, uses implicit feedback to manipulate spontaneous activity at the network level, without violating the spontaneous or endogenous nature of the signal inherent in other techniques like TMS (transcranial magnetic stimulation). As a result, it may also provide a means for directly testing network causality.

Upon conclusion of this course, learners will be able to:

1. Explain the use of fluctuating, spontaneous neural activity for predicting cognitive task performance.

2. Describe a newly developed method using functional magnetic imaging (fMRI) to modify aberrant neurocircuitry in the human brain.

3. List new advances in neuroimaging - especially regarding developing implicit procedures for potentially changing the neural substrates of cognition and modifying behavior.


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Alex Martin, PhD
Dr. Martin received his B.A. from the City College of New York and his Ph.D. from the City University of New York. He did his post-doctoral work at the National Institute of Neurological Disorders and Stroke on the breakdown of language and memory processes in Alzheimer's disease. In 1985 he joined the faculty of the Uniformed Services University of the Health Sciences where he studied cognitive dysfunction associated with HIV infection. In 1990 he moved to the National Institute of Mental Health, NIH, where he continued his work on cognitive abnormalities in neuropsychiatric disorders, and on elucidating the neural circuitry associated with specific perceptual, memory, and social functions in the normally developing brain using functional brain imaging technologies. His work has been cited more than 44,000 times. He is the Chief of the Cognitive Neuropsychology Section of the Laboratory of Brain and Cognition, and the Acting Chief of that Laboratory.