Gun violence is a national public health epidemic with significant effects on individuals, families and communities. Death by firearm has become the number one cause of death for children and adolescents in the United States. Primary care providers need to be on the front line in helping patients, families and their communities in early detection and prevention of gun violence. Patient cases, along with recommendations from the American Academy of Family Physicians (AAFP) and the American Psychological Association (APA), will be reviewed. Routine screening, advice for patients, preventive strategies aimed at individual, practice community levels, will also be discussed.