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EMBO e-talks: Self-organizing biochemical networks driving specialization and division of labor in cell groups

Description

Speakers: John O’Neill (YIP-2016) and Markus Ralser (YIP-2011)

Moderator: Sunil Laxman (GIN-2020)

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Talk description: We are interested in understanding organizational principles of metabolic regulation, and how that regulates cell states. In particular, using simple yeasts, we have asked how self-organizing biochemical/metabolic processes can enable new resource production, creating new environments that allow different (heterogeneous) cell states to co-exist in seemingly uniform environments. Our interdisciplinary approach goes from systems level analysis to molecular mechanisms, and integrates mathematical models where appropriate.

Time

Apr 7, 2021 02:00 PM in Amsterdam, Berlin, Rome, Stockholm, Vienna

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Message preview	Hi there, You are invited to a Zoom webinar. When: Apr 7, 2021 02:00 PM Amsterdam, Berlin, Rome, Stockholm, Vienna Topic: EMBO e-talks: Self-organizing biochemical networks driving specialization and division of labor in cell groups Register in advance for this webinar: https://us02web.zoom.us/webinar/register/WN_yi-ViIrUR36pEoBMoQdCSA After registering, you will receive a confirmation email containing information about joining the webinar. ---------- Webinar Speakers Markus Ralser (@Charité University Medicine, Berlin, DE) Markus Ralser, Prof. Dr. Mag. (*1980), was born in South Tyrol (Italy), and studied Genetics and Molecular Biology In Salzburg (Austria) and completed a PhD with Sylvia Krobitsch and Hans Lehrach in Neurodegenerative disorders at the Max Planck Institute for Molecular Genetics in Berlin (Germany). Since 2018, he has a dual appointment between the Francis Crick Institute where he is a Senior Group Leader, and the Charité University Medicine, were as Einstein Professor of Biochemistry, he heads the Biochemistry Department. Markus Ralser is the recipient of several notable science awards which includes two ERC grants, the Wellcome Beit Prize, the BioMed Central Research Award, the Colworth Medal of the Biochemical Society, the Starling Medal of the Endocrinological Society, and the EMBO Gold Medal. Markus Ralser's lab is known for work on the fundamental principles of cellular metabolism, that entails development of new technologies for measuring metabolites and proteins at a large scale. John O'Neill (@MRC Laboratory of Molecular Biology, Cambridge, UK) John O'Neill studied Biochemistry at New College, Oxford, and then did his PhD research on cAMP signalling and the mammalian circadian pacemaker at the MRC Laboratory of Molecular Biology in Cambridge with Michael Hastings. As a post-doc, he studied circadian rhythms in plants and algae with Andrew Millar (Edinburgh) and then human cells then at the Institute of Metabolic Science in Cambridge. John was awarded a Wellcome Trust Career Development Fellowship in 2011, and in 2013 was recruited to become a group leader in the Cell Biology Division of the LMB. The O’Neill group is interested in the fundamental mechanisms that sustain circadian rhythms in eukaryotic cells, how this endogenous clock evolved, and how daily timekeeping bestows an adaptive advantage upon specific mammalian cellular functions. Sunil Laxman (@Institute for Stem Cell Biology and Regenerative Medicine, Bangalore, IN) The Laxman lab at inStem, Bangalore, addresses the organizational principles of metabolic regulation at both a systems and molecular levels. The lab addresses what makes some metabolites special in their ability to control cell states, how they are sensed within cells, and in building a contextual logic of how metabolic networks are organized within and between cells. These studies are carried out using various budding yeasts as 'model systems', as well as other cells and model organisms. Sunil Laxman studied engineering as an undergraduate, completed a PhD in Pharmacology on cyclic nucleotide signaling with Prof. Joe Beavo, and carried out postdoctoral research in biochemistry in the laboratories of Profs. Steven McKnight and Benjamin Tu.

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